- Week 12 of the college football season begins in earnest Thursday night when Louisville visits Duke
- The top matchup of the week has #7 Michigan State traveling to #4 Ohio State
- The full list of Week 12 opening lines and odds can be found below with predictions
A showdown in the Big Ten highlights the action in Week 12 of college football.
#4 Ohio State will host #7 Michigan State at 12:00 p.m. ET Saturday in a matchup of 9-1 teams at Ohio Stadium in Columbus. The Buckeyes have opened as 19.5-point favorites.
Ohio State is 7-0 in conference play and holds a one-game lead over Michigan State (6-1) and Michigan (6-1). Michigan State has the head-to-head tiebreaker over Michigan. The Wolverines host the Buckeyes on Nov. 27 in the regular-season finale.
The two Pac-12 division leaders square off as #3 Oregon (9-1) visits #24 Utah (7-3) at 7:30 p.m. ET Saturday at Rice-Eccles Stadium in Salt Lake City. The Ducks top the North and the Utes pace the South. The Utes are 2.5-point favorites.
Both games will be televised by ABC.
Here is a look at all the college football Week 12 spreads:
College Football Week 12 Opening Odds
Game Time (Eastern) | Team | Spread | Moneyline |
---|---|---|---|
Thursday, Nov. 18 | Louisville | -19 (-110) | OFF |
7:30 p.m. | Duke | +19 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 19 | Memphis | +10 (-110) | OFF |
9:00 p.m. | Houston | -10 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Friday, Nov. 19 | Arizona | +15.5 (-110) | OFF |
9:00 p.m. | Washington State | -15.5 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Friday, Nov. 19 | San Diego State | -12 (-110) | OFF |
11:30 p.m. | UNLV | +12 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Florida State | +3 (-110) | OFF |
12:00 p.m. | Boston College | -3 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | New Mexico State | +35.5 (-110) | OFF |
12:00 p.m. | Kentucky | -35.5 (-110) | XXX |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Purdue | -11.5 (-110) | OFF |
12:00 p.m. | Northwestern | +11.5 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Iowa State | +6.5 (-110) | OFF |
12:00 p.m. | Oklahoma | -6.5 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Rutgers | +16.5 (-110) | OFF |
12:00 p.m. | Penn State | -16.5 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | South Florida | +3.5 (-110) | OFF |
12:00 p.m. | Tulane | -3.5 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Texas | +1 (-110) | OFF |
12:00 p.m. | West Virginia | -1 (-110 | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Michigan State | +19.5 (-110) | OFF |
12:00 p.m. | Ohio State | -19.5 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Wake Forest | +3.5 (-110) | OFF |
12:00 p.m. | Clemson | -3.5 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Illinois | +13 (-110) | OFF |
2:00 p.m. | Iowa | -13 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Georgia Tech | +14.5 (-110) | OFF |
2:30 p.m. | Notre Dame | -14.5 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Washington | -6.5 (-110) | OFF |
3:00 p.m. | Colorado | +6.5 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Arkansas | +22.5 (-110) | OFF |
3:30 p.m. | Alabama | -22.5 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | SMU | +12.5 (-110) | OFF |
3:30 p.m. | Cincinnati | -12.5 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Minnesota | -6.5 (-110) | OFF |
3:30 p.m. | Indiana | +6.5 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Virginia | +11.5 (-110) | OFF |
3:30 p.m. | Pittsburgh | -11.5 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | UAB | +6 (-110) | OFF |
3:30 p.m. | UTSA | -6 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday. Nov. 20 | Nebraska | +10.5 (-110) | OFF |
3:30 p.m. | Wisconsin | -10.5 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Michigan | -15 (-110) | OFF |
3:30 p.m. | Maryland | +15 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | East Carolina | -4 (-110) | OFF |
3:30 p.m. | Navy | +4 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Florida | -7.5 (-110) | OFF |
4:00 p.m. | Missouri | +7.5 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Syracuse | +11 (-110) | OFF |
4:00 p.m. | North Carolina State | -11 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Kansas | +21.5 (-110) | OFF |
4:00 p.m. | TCU | -21.5 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Temple | +21 (-110) | OFF |
4:00 p.m. | Tulsa | -21 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Connecticut | +30.5 (-110) | OFF |
4:00 p.m. | UCF | -30.5 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | UCLA | -2.5 (-110) | OFF |
4:00 p.m. | USC | +2.5 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | BYU | -20.5 (-110) | OFF |
4:00 p.m. | Georgia Southern | +20.5 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Louisiana-Lafayette | +4.5 (-110) | OFF |
4:00 p.m. | Liberty | -4.5 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Baylor | Pk (-110) | OFF |
5:30 p.m. | Kansas State | Pk (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | California | -4.5 (-110) | OFF |
7:00 p.m. | Stanford | +4.5 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Auburn | -11.5 (-110) | OFF |
7:00 p.m. | South Carolina | +11.5 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Virginia Tech | +7 (-110) | OFF |
7:30 p.m. | Miami | -7 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Vanderbilt | +37.5 (-110) | OFF |
7:30 p.m. | Mississippi | -37.5 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | South Alabama | +28 (-110) | OFF |
7:30 p.m. | Tennessee | -28 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Oregon | +2.5 (-110) | OFF |
7:30 p.m. | Utah | -2.5 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Oklahoma State | -10 (-110) | OFF |
8:00 p.m. | Texas Tech | +10 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Louisiana-Monroe | +30.5 (-110) | OFF |
9:00 p.m. | LSU | -30.5 (-110) | OFF |
Game Time (Eastern) | Team | Spread | Moneyline |
Saturday, Nov. 20 | Arizona State | -2.5 (-110) | OFF |
10:30 p.m. | Oregon State | +2.5 (-110) | OFF |
Odds as of November 14th at DraftKings.
OSU-MSU Pivotal Big Ten Game
Michigan State bounced back from its first loss of the season to beat Maryland 40-21 at home on Saturday.
Payton Thorne threw two of his four touchdown passes to Jayden Reed. Kenneth Walker III ran for 143 yards and two scores.
Payton Thorne DIME to Jayden Reed for the 29 yard TD! #Sparty pic.twitter.com/3moYWGdk8Q
— ✯✯✯✯✯ (@FTBVids_YT) November 13, 2021
C.J. Stroud threw for 361 yards and five touchdowns to led Ohio State to a 59-31 victory over visiting Purdue. Freshman TreVeyon Henderson rushed for two scores.
Garrett Wilson, who was unavailable last week for unspecified reasons, had 10 catches for 126 yards and three touchdowns. Jaxson Smith-Njigba had nine catches for 139 yards and a TD.
No. 4 @OhioStateFB‘s offense is so scary. ?@GarrettWilson_V has his 2nd TD today, and it’s 35-7 early in the 2Q. pic.twitter.com/fzRkaFu4iq
— Big Ten Network (@BigTenNetwork) November 13, 2021
Ohio State is playing well but look for Michigan State to try to control the clock with Walker, which should make it a reasonably close game.
The Pick: Michigan State +19.5 (-110)
Dukes-Utes Pac-12 Championship Preview?
Oregon downed Washington State 38-24 at home on Saturday as Anthony Brown Jr. threw for 135 yards and a touchdown while rushing for 123 yards and another score.
What a dive from @anthonybrown_2. ??
? @ESPN
?https://t.co/QySOuiL5bL#GoDucks | #Pac12FB pic.twitter.com/ncne5xugfi— Pac-12 Conference (@pac12) November 14, 2021
Travis Dye ran for 88 yards and a score for the Ducks, who won their fifth straight game, and had 25 yards receiving and another TD.
Utah won its third straight game but struggled to beat lowly Arizona 38-29 on the road as Cameron Rising threw for 294 yards and two touchdowns and T.J. Pledger ran for 119 yards and two TDs.
Up just 31-29, Utah finally closed the game with a 15-play, 75-yard drive that lasted more than eight minutes. It was capped by Pledger’s 2-yard touchdown run with 2:10 left.
Utah certainly looked a team that was peeking ahead to Oregon on Saturday. However, Rising and Pledger give Utes the kind of offensive firepower needed to take down the Ducks.
Cameron Rising tallied nearly 300 passing yards today as he connects with Dalton Kincaid in the redzone pic.twitter.com/DSyLEIhIaj
— Stadium (@Stadium) November 13, 2021
The Pick: Utah -2.5 (-110)
Out of Line?
UCF is favored by 30.5 points at home over Connecticut and TCU is a 21.5-point choice over visiting Kansas on Saturday. Both lines are certainly substantial but also seem a little light.
UConn is bad, like really bad. Kansas isn’t as good as its 58-57 overtime stunner at Texas on Saturday indicates and TCU is better than its 63-17 blowout loss at Oklahoma State.
The sharps realize UConn is a team to fade and TCU is undervalued. So, look for both lines to trend upward this week.
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